Abstract
Neurobiological models for obsessive-compulsive disorder (OCD) have consistently implicated the caudate nucleus in the pathophysiology of this disorder. OCD symptoms improved markedly in a 9-year-old boy treated with paroxetine, a selective serotonin reuptake inhibitor, for whom pre/posttreatment proton magnetic resonance spectroscopic examinations were acquired to assess the relationship between neurochemical profile in the caudate nucleus, symptom severity, and treatment with paroxetine. Striking changes of the glutamate resonance in the caudate were observed after 12 weeks of paroxetine treatment. These data provide further support for glutamatergic-serotonin pathway involvement in the caudate nucleus of OCD patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 663-667 |
| Number of pages | 5 |
| Journal | Journal of the American Academy of Child and Adolescent Psychiatry |
| Volume | 37 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1998 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Developmental and Educational Psychology
- Psychiatry and Mental health
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