CaV1.2 calcium channels: Just cut out to be regulated?

Rachel D. Groth, Natasha N. Tirko, Richard W. Tsien

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations

Abstract

Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis etal. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.

Original languageEnglish (US)
Pages (from-to)939-940
Number of pages2
JournalNeuron
Volume82
Issue number5
DOIs
StatePublished - Jun 4 2014

All Science Journal Classification (ASJC) codes

  • General Neuroscience

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