CaV1.2 calcium channels: Just cut out to be regulated?

Rachel D. Groth; Natasha N. Tirko; Richard W. Tsien

doi:10.1016/j.neuron.2014.05.030

Ca_V1.2 calcium channels: Just cut out to be regulated?

Rachel D. Groth
, Natasha N. Tirko
, Richard W. Tsien

One Health Microbiome Center

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

Tight regulation of calcium entry through the L-type calcium channel Ca_V1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis etal. (2014) demonstrate that Ca_V1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.

Original language	English (US)
Pages (from-to)	939-940
Number of pages	2
Journal	Neuron
Volume	82
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2014.05.030
State	Published - Jun 4 2014

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neuron.2014.05.030

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title = "CaV1.2 calcium channels: Just cut out to be regulated?",

abstract = "Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis etal. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.",

author = "Groth, \{Rachel D.\} and Tirko, \{Natasha N.\} and Tsien, \{Richard W.\}",

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T2 - Just cut out to be regulated?

AU - Groth, Rachel D.

AU - Tirko, Natasha N.

AU - Tsien, Richard W.

PY - 2014/6/4

Y1 - 2014/6/4

N2 - Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis etal. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.

AB - Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis etal. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.

UR - https://www.scopus.com/pages/publications/84901771800

UR - https://www.scopus.com/pages/publications/84901771800#tab=citedBy

U2 - 10.1016/j.neuron.2014.05.030

DO - 10.1016/j.neuron.2014.05.030

M3 - Short survey

C2 - 24908477

AN - SCOPUS:84901771800

SN - 0896-6273

VL - 82

SP - 939

EP - 940

JO - Neuron

JF - Neuron

IS - 5

ER -

Ca_V1.2 calcium channels: Just cut out to be regulated?

Abstract

All Science Journal Classification (ASJC) codes

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