Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

S. J. Benkovic, A. D. Napper, R. A. Lerner

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

Original languageEnglish (US)
Pages (from-to)5355-5358
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number15
StatePublished - Aug 1988

All Science Journal Classification (ASJC) codes

  • General


Dive into the research topics of 'Catalysis of a stereospecific bimolecular amide synthesis by an antibody.'. Together they form a unique fingerprint.

Cite this