Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

S. J. Benkovic; A. D. Napper; R. A. Lerner

doi:10.1073/pnas.85.15.5355

Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

S. J. Benkovic
, A. D. Napper
, R. A. Lerner

Chemistry

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

Original language	English (US)
Pages (from-to)	5355-5358
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	85
Issue number	15
DOIs	https://doi.org/10.1073/pnas.85.15.5355
State	Published - Aug 1988

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10.1073/pnas.85.15.5355

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title = "Catalysis of a stereospecific bimolecular amide synthesis by an antibody.",

abstract = "We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.",

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AU - Napper, A. D.

AU - Lerner, R. A.

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Y1 - 1988/8

N2 - We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

AB - We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

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UR - https://www.scopus.com/pages/publications/0024059280#tab=citedBy

U2 - 10.1073/pnas.85.15.5355

DO - 10.1073/pnas.85.15.5355

M3 - Article

C2 - 3399496

AN - SCOPUS:0024059280

SN - 0027-8424

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -

Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

Abstract

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