Catalyst-Based Biomolecular Logic Gates

Dennis S. Winston, David D. Boehr

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Regulatory processes in biology can be re-conceptualized in terms of logic gates, analogous to those in computer science. Frequently, biological systems need to respond to multiple, sometimes conflicting, inputs to provide the correct output. The language of logic gates can then be used to model complex signal transduction and metabolic processes. Advances in synthetic biology in turn can be used to construct new logic gates, which find a variety of biotechnology applications including in the production of high value chemicals, biosensing, and drug delivery. In this review, we focus on advances in the construction of logic gates that take advantage of biological catalysts, including both protein-based and nucleic acid-based enzymes. These catalyst-based biomolecular logic gates can read a variety of molecular inputs and provide chemical, optical, and electrical outputs, allowing them to interface with other types of biomolecular logic gates or even extend to inorganic systems. Continued advances in molecular modeling and engineering will facilitate the construction of new logic gates, further expanding the utility of biomolecular computing.

Original languageEnglish (US)
Article number712
Issue number7
StatePublished - Jul 2022

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Environmental Science
  • Physical and Theoretical Chemistry


Dive into the research topics of 'Catalyst-Based Biomolecular Logic Gates'. Together they form a unique fingerprint.

Cite this