Catalytic antibodies: Perusing combinatorial libraries

Bruce Posner, Jeffrey Smiley, Irene Lee, Stephen Benkovic

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Combinatorial libraries are a promising alternative for isolating catalytic antibodies produced by the immune system in response to the transition-state analog of a given reaction. Large, diverse panels of antibodies with high affinity for the transition-state analog can be isolated using screening or selection approaches. Furthermore, we have estimated that nucleotide sequences that bear close similarity to the sequence for a known catalytic antibody occur in combination at frequencies sufficient for their detection in such libraries.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalTrends in Biochemical Sciences
Issue number4
StatePublished - Apr 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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