Catalytic antibodies with lipase activity and R or S substrate selectivity

Kim D. Janda; Stephen J. Benkovic; Richard A. Lerner

doi:10.1126/science.2717936

Catalytic antibodies with lipase activity and R or S substrate selectivity

Kim D. Janda, Stephen J. Benkovic, Richard A. Lerner

Chemistry

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (10³ to 10⁵) above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.

Original language	English (US)
Pages (from-to)	437-440
Number of pages	4
Journal	Science
Volume	244
Issue number	4903
DOIs	https://doi.org/10.1126/science.2717936
State	Published - 1989

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title = "Catalytic antibodies with lipase activity and R or S substrate selectivity",

abstract = "The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (103 to 105) above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.",

author = "Janda, {Kim D.} and Benkovic, {Stephen J.} and Lerner, {Richard A.}",

year = "1989",

doi = "10.1126/science.2717936",

language = "English (US)",

volume = "244",

pages = "437--440",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4903",

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T1 - Catalytic antibodies with lipase activity and R or S substrate selectivity

AU - Janda, Kim D.

AU - Benkovic, Stephen J.

AU - Lerner, Richard A.

PY - 1989

Y1 - 1989

N2 - The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (103 to 105) above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.

AB - The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (103 to 105) above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.

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UR - http://www.scopus.com/inward/citedby.url?scp=0024584165&partnerID=8YFLogxK

U2 - 10.1126/science.2717936

DO - 10.1126/science.2717936

M3 - Article

C2 - 2717936

AN - SCOPUS:0024584165

SN - 0036-8075

VL - 244

SP - 437

EP - 440

JO - Science

JF - Science

IS - 4903

ER -

Catalytic antibodies with lipase activity and R or S substrate selectivity

Abstract

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