Catechol-bearing block copolymer micelles: Structural characterization and antioxidant activity

Urara Hasegawa, Masaki Moriyama, Hiroshi Uyama, André J. Van Der Vlies

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Oxidative stress caused by uncontrolled production of reactive oxygen species (ROS) has been linked to the initiation and progression of some diseases. Therefore, the use of antioxidants capable of scavenging ROS has attracted growing interest. We recently reported antioxidant micelles having catechol moieties, a structural motif found among natural antioxidants. These micelles showed a strong inhibitory effect in ROS-mediated angiogenesis as compared to the small catecholic compound dopamine. Here, we aim to explain this interesting function of the micelles by correlating the effects of self-assembled structures on the auto-oxidation stability and anti-angiogenic activity. The micelles were prepared from a hydrophilic poly(N-acryloyl morpholine) and a hydrophobic catechol-bearing block with different catechol content. The micelles with higher catechol content formed stable spherical micelles and showed increased stability against auto-oxidation, while micellization did not affect the redox potential of catechol moieties. Furthermore, the micelles with higher catechol content showed a stronger anti-angiogenic activity.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
StatePublished - Jun 1 2015

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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