Catecholamine metabolism during heroin use

J. J. Schildkraut; R. E. Meyer; P. J. Orsulak; S. M. Mirin; M. Roffman; P. A. Platz; E. Grab; M. E. Randall; M. McDougle

doi:10.1176/ajp.134.5.534

Catecholamine metabolism during heroin use

J. J. Schildkraut, R. E. Meyer, P. J. Orsulak, S. M. Mirin, M. Roffman, P. A. Platz, E. Grab, M. E. Randall, M. McDougle

Department of Psychiatry and Behavioral Health

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The authors examined urinary levels of catecholamines and metabolites during a 10-day period of heroin use in 9 subjects. Catecholamine and metabolite excretion increased over baseline values on the first day of heroin use, but markedly different patterns of change emerged later. In contrast to the significant increase in normetanephrine and decrease in metanephrine excretion in all 9 subjects during heroin use, only 4 subjects showed an increase in 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion. Moreover, it appeared that the increase in MHPG excretion in this subgroup began on the day before heroin administration, which suggests the possibility of an anticipatory or conditioned response.

Original language	English (US)
Pages (from-to)	534-537
Number of pages	4
Journal	Unknown Journal
Volume	134
Issue number	5
DOIs	https://doi.org/10.1176/ajp.134.5.534
State	Published - 1977

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health

UN SDGs

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10.1176/ajp.134.5.534

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title = "Catecholamine metabolism during heroin use",

abstract = "The authors examined urinary levels of catecholamines and metabolites during a 10-day period of heroin use in 9 subjects. Catecholamine and metabolite excretion increased over baseline values on the first day of heroin use, but markedly different patterns of change emerged later. In contrast to the significant increase in normetanephrine and decrease in metanephrine excretion in all 9 subjects during heroin use, only 4 subjects showed an increase in 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion. Moreover, it appeared that the increase in MHPG excretion in this subgroup began on the day before heroin administration, which suggests the possibility of an anticipatory or conditioned response.",

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T1 - Catecholamine metabolism during heroin use

AU - Schildkraut, J. J.

AU - Meyer, R. E.

AU - Orsulak, P. J.

AU - Mirin, S. M.

AU - Roffman, M.

AU - Platz, P. A.

AU - Grab, E.

AU - Randall, M. E.

AU - McDougle, M.

PY - 1977

Y1 - 1977

N2 - The authors examined urinary levels of catecholamines and metabolites during a 10-day period of heroin use in 9 subjects. Catecholamine and metabolite excretion increased over baseline values on the first day of heroin use, but markedly different patterns of change emerged later. In contrast to the significant increase in normetanephrine and decrease in metanephrine excretion in all 9 subjects during heroin use, only 4 subjects showed an increase in 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion. Moreover, it appeared that the increase in MHPG excretion in this subgroup began on the day before heroin administration, which suggests the possibility of an anticipatory or conditioned response.

AB - The authors examined urinary levels of catecholamines and metabolites during a 10-day period of heroin use in 9 subjects. Catecholamine and metabolite excretion increased over baseline values on the first day of heroin use, but markedly different patterns of change emerged later. In contrast to the significant increase in normetanephrine and decrease in metanephrine excretion in all 9 subjects during heroin use, only 4 subjects showed an increase in 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion. Moreover, it appeared that the increase in MHPG excretion in this subgroup began on the day before heroin administration, which suggests the possibility of an anticipatory or conditioned response.

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Catecholamine metabolism during heroin use

Abstract

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