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Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323
Mark L. Lupher
, Navin Rao
, Nancy L. Lill
, Christopher E. Andoniou
, Sachiko Miyake
, Edward A. Clark
, Brian Druker
, Hamid Band
Penn State Cancer Institute
Cancer Institute, Mechanisms of Carcinogenesis
Research output
:
Contribution to journal
›
Article
›
peer-review
160
Scopus citations
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Dive into the research topics of 'Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323'. Together they form a unique fingerprint.
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Keyphrases
Phosphotyrosine
100%
Negative Regulation
100%
Syk Kinase
100%
Phosphotyrosine Binding Domains
100%
COS-7 Cells
60%
Phosphorylation
40%
CD-8
40%
Hybrid Method
20%
Dose Effect
20%
Protein Level
20%
SH3 Domain
20%
Point mutation
20%
Physical Interaction
20%
Oncogene
20%
Caenorhabditis Elegans
20%
Gain-of-function mutation
20%
Yeast Two-hybrid
20%
Co-expression
20%
Kinase Domain
20%
Negative Regulator
20%
Heterologous Expression
20%
Linker Region
20%
Oncogene Products
20%
Biochemistry, Genetics and Molecular Biology
Receptor Tyrosine Kinase
100%
Tyrosine Kinase
100%
Phosphotyrosine-Binding Domain
100%
Syk
100%
CD8
14%
Kinase
7%
Phosphotransferase
7%
Point Mutation
7%
N-Terminus
7%
Caenorhabditis Elegans
7%
Yeast Two-Hybrid Screening
7%
Proto Oncogene
7%
Heterologous Expression
7%
Loss of Function Mutation
7%