TY - JOUR
T1 - cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases
AU - Shao, H.
AU - Lou, L.
AU - Pandey, A.
AU - Verderame, Michael
AU - Siever, D. A.
AU - Dixit, V. M.
PY - 1995/2/24
Y1 - 1995/2/24
N2 - We have isolated a murine cDNA encoding a ligand for the Cek7 receptor protein-tyrosine kinase (RPTK), a member of the Eph/Eck RPTK subfamily. Sequence analysis predicts an open reading frame of 209 amino acids with a predicted molecular mass of 24 kDa. The Cek7 ligand shows a 48% sequence identity at the protein level to B61, a ligand for the related Eck RPTK, 30% to the Cek5 ligand, 59% to the recently cloned Ehk1-L, and identity to ELF- 1, a recently described ligand for the Mek4 and Sek RPTKs. The expressed Cek7 ligand is functionally active as it induces autophosphorylation of the Cek7 RPTK.
AB - We have isolated a murine cDNA encoding a ligand for the Cek7 receptor protein-tyrosine kinase (RPTK), a member of the Eph/Eck RPTK subfamily. Sequence analysis predicts an open reading frame of 209 amino acids with a predicted molecular mass of 24 kDa. The Cek7 ligand shows a 48% sequence identity at the protein level to B61, a ligand for the related Eck RPTK, 30% to the Cek5 ligand, 59% to the recently cloned Ehk1-L, and identity to ELF- 1, a recently described ligand for the Mek4 and Sek RPTKs. The expressed Cek7 ligand is functionally active as it induces autophosphorylation of the Cek7 RPTK.
UR - http://www.scopus.com/inward/record.url?scp=0028910215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028910215&partnerID=8YFLogxK
U2 - 10.1074/jbc.270.8.3467
DO - 10.1074/jbc.270.8.3467
M3 - Article
C2 - 7876076
AN - SCOPUS:0028910215
SN - 0021-9258
VL - 270
SP - 3467
EP - 3470
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 8
ER -