@article{07cc5af910cd4350bc949342218e974d,
title = "Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development",
abstract = "Many cell culture and animal models have been used to study hepatitis B virus (HBV) replication and its effects in the liver; these have facilitated development of strategies to control and clear chronic HBV infection. We discuss the advantages and limitations of systems for studying HBV and developing antiviral agents, along with recent advances. New and improved model systems are needed. Cell culture systems should be convenient, support efficient HBV infection, and reproduce responses of hepatocytes in the human body. We also need animals that are fully permissive to HBV infection, convenient for study, and recapitulate human immune responses to HBV and effects in the liver. High-throughput screening technologies could facilitate drug development based on findings from cell and animal models.",
author = "Jianming Hu and Lin, {You Yu} and Chen, {Pei Jer} and Koichi Watashi and Takaji Wakita",
note = "Funding Information: Funding J.H. was supported by grants AI043453, AI074982, AI77532, and AI27670 from the National Institutes of Health. P.J.C. was supported by grants MOST-106-2321-B-002-011-, MOST-106-2811-B-002-074-, and MOST-107-3017-F-002-002 from the Ministry of Science and Technology, Executive Yuan, Taiwan; NTU-107L9014-1 from the Center of Precision Medicine, National Taiwan University; and the Liver Disease Prevention & Treatment Research Foundation. P.J.C. acknowledges financial support from the “Center of Precision Medicine” from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. K.W. was supported by the Japan Society for the Promotion of Science KAKENHI (JP17H04085, JP66KT0111), JST CREST program, and the Japan Agency for Medical Research and Development (AMED) (18fk0310114j0002, 18fk0310103j0202, 18fk0310101j1002, 18fk0210036j0001, 18fm0208019j0002). T.W. was supported by the Japan Agency for Medical Research and Development (AMED) (18fk0310103j0002, 18fk0210009j0003, 18fk0210015j0203, 18fk0210020j1002, 18jk0210003j0001) and by the Japan Society for the Promotion of Science KAKENHI (JP17K09447). Publisher Copyright: {\textcopyright} 2019 AGA Institute",
year = "2019",
month = jan,
doi = "10.1053/j.gastro.2018.06.093",
language = "English (US)",
volume = "156",
pages = "338--354",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "2",
}
