Cell competition and its possible relation to cancer

Nicholas E. Baker; Wei Li

doi:10.1158/0008-5472.CAN-07-6348

Cell competition and its possible relation to cancer

Nicholas E. Baker, Wei Li

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

Cell competition can occur when cells of different genotypes share the same developing compartment, with one genotype displacing the other as a result of a proliferative advantage. Studies of cell competition in Drosophila have identified an active process of cell assassination and corpse engulfment, and also roles for Myc and the Warts/Hippo tumor suppressor pathway. Here, we discuss the possible relevance of cell competition to cancer.

Original language	English (US)
Pages (from-to)	5505-5507
Number of pages	3
Journal	Cancer Research
Volume	68
Issue number	14
DOIs	https://doi.org/10.1158/0008-5472.CAN-07-6348
State	Published - Jul 15 2008

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1158/0008-5472.CAN-07-6348

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AB - Cell competition can occur when cells of different genotypes share the same developing compartment, with one genotype displacing the other as a result of a proliferative advantage. Studies of cell competition in Drosophila have identified an active process of cell assassination and corpse engulfment, and also roles for Myc and the Warts/Hippo tumor suppressor pathway. Here, we discuss the possible relevance of cell competition to cancer.

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Cell competition and its possible relation to cancer

Abstract

All Science Journal Classification (ASJC) codes

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