TY - JOUR
T1 - Central control of gastrointestinal motility
AU - Browning, Kirsteen N.
AU - Travagli, R. Alberto
N1 - Funding Information:
This work was supported by NIH grants DK 78364 (KNB), DK 55530, and DK 99350 (AT).
Funding Information:
This work was supported by NIH grants DK (KNB), DK 55530, and DK 99350 (AT).
Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Purpose of reviewThis review summarizes the organization and structure of vagal neurocircuits controlling the upper gastrointestinal tract, and more recent studies investigating their role in the regulation of gastric motility under physiological, as well as pathophysiological, conditions.Recent findingsVagal neurocircuits regulating gastric functions are highly plastic, and open to modulation by a variety of inputs, both peripheral and central. Recent research in the fields of obesity, development, stress, and neurological disorders highlight the importance of central inputs onto these brainstem neurocircuits in the regulation of gastric motility.SummaryRecognition of the pivotal role that the central nervous system exerts in the regulation, integration, and modulation of gastric motility should serve to encourage research into central mechanisms regulating peripheral motility disorders.
AB - Purpose of reviewThis review summarizes the organization and structure of vagal neurocircuits controlling the upper gastrointestinal tract, and more recent studies investigating their role in the regulation of gastric motility under physiological, as well as pathophysiological, conditions.Recent findingsVagal neurocircuits regulating gastric functions are highly plastic, and open to modulation by a variety of inputs, both peripheral and central. Recent research in the fields of obesity, development, stress, and neurological disorders highlight the importance of central inputs onto these brainstem neurocircuits in the regulation of gastric motility.SummaryRecognition of the pivotal role that the central nervous system exerts in the regulation, integration, and modulation of gastric motility should serve to encourage research into central mechanisms regulating peripheral motility disorders.
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U2 - 10.1097/MED.0000000000000449
DO - 10.1097/MED.0000000000000449
M3 - Review article
C2 - 30418187
AN - SCOPUS:85059153154
SN - 1752-296X
VL - 26
SP - 11
EP - 16
JO - Current Opinion in Endocrinology, Diabetes and Obesity
JF - Current Opinion in Endocrinology, Diabetes and Obesity
IS - 1
ER -
