Central control of gastrointestinal motility

Kirsteen N. Browning, R. Alberto Travagli

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Purpose of reviewThis review summarizes the organization and structure of vagal neurocircuits controlling the upper gastrointestinal tract, and more recent studies investigating their role in the regulation of gastric motility under physiological, as well as pathophysiological, conditions.Recent findingsVagal neurocircuits regulating gastric functions are highly plastic, and open to modulation by a variety of inputs, both peripheral and central. Recent research in the fields of obesity, development, stress, and neurological disorders highlight the importance of central inputs onto these brainstem neurocircuits in the regulation of gastric motility.SummaryRecognition of the pivotal role that the central nervous system exerts in the regulation, integration, and modulation of gastric motility should serve to encourage research into central mechanisms regulating peripheral motility disorders.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Issue number1
StatePublished - Feb 1 2019

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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