TY - JOUR
T1 - Central Gustatory Lesions
T2 - II. Effects on Sodium Appetite, Taste Aversion Learning, and Feeding Behaviors
AU - Flynn, Francis W.
AU - Grill, Harvey J.
AU - Schulkin, Jay
AU - Norgren, Ralph
PY - 1991/12
Y1 - 1991/12
N2 - Intake and taste reactivity tests were used to determine the effects of bilateral lesions of the gustatory portions of the nucleus of the solitary tract (NST), the parabrachial nucleus (PBN), and the ventral posteromedial nucleus of the thalamus (VPMpc) on several complex ingestive behaviors. In the 1st experiment, lesions of the PBN and the NST blocked, and VPMpc lesions impaired, the behavioral expression of salt appetite. In the 2nd experiment, alanine was paired with injections of LiCl. Control rats as well as rats with NST and VPMpc lesions acquired the taste aversion, but rats with PBN lesions did not. In the 3rd experiment, all animals increased their food intake after injections of 2 U/kg insulin and 250 mg/kg 2-deoxy-D-glucose, and their food intake was suppressed after nutritive stomach loads.
AB - Intake and taste reactivity tests were used to determine the effects of bilateral lesions of the gustatory portions of the nucleus of the solitary tract (NST), the parabrachial nucleus (PBN), and the ventral posteromedial nucleus of the thalamus (VPMpc) on several complex ingestive behaviors. In the 1st experiment, lesions of the PBN and the NST blocked, and VPMpc lesions impaired, the behavioral expression of salt appetite. In the 2nd experiment, alanine was paired with injections of LiCl. Control rats as well as rats with NST and VPMpc lesions acquired the taste aversion, but rats with PBN lesions did not. In the 3rd experiment, all animals increased their food intake after injections of 2 U/kg insulin and 250 mg/kg 2-deoxy-D-glucose, and their food intake was suppressed after nutritive stomach loads.
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U2 - 10.1037/0735-7044.105.6.944
DO - 10.1037/0735-7044.105.6.944
M3 - Article
C2 - 1777107
AN - SCOPUS:0026002463
SN - 0735-7044
VL - 105
SP - 944
EP - 954
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 6
ER -