Cerebral infarction in patients with nephrotic syndrome

E. Eugene Marsh, José Biller, Harold P. Adams, Jeffrey M. Kaplan

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


We describe two adult patients who presented with acute cerebral infarction and were found to have a hypercoagulable state due to nephrotic syndrome. One patient had a deficiency of free protein-S. The other patient had a pulmonary em bolus 4 months after the stroke. Our cases demonstrate that the hypercoagulable state associated with nephrotic syndrome can be associated with cerebral arterial thrombosis and infarction in adults. Examination of the urine remains an important part of the evaluation of patients with recent stroke. The presence of severe proteinuria and a low serum albumin content should prompt consideration of a hypercoagulable state. Our experience suggests that anticoagulant drugs may be required to reduce the risk of new thrombotic events.

Original languageEnglish (US)
Pages (from-to)90-93
Number of pages4
Issue number1
StatePublished - Jan 1991

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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