@article{bb5092d6463c466bb65f5ea5f0b5ebc8,
title = "Changes in ovarian follicles following acute infection with bovine viral diarrhea virus",
abstract = "Bovine viral diarrhea virus (BVDV) has been associated with several reproductive problems in cattle, including poor fertility, early embryonic deaths, abortion and congenital anomalies. Little is known about the cause of poor fertility in cows acutely infected with BVDV. The purpose of this study was to identify changes in ovarian function following acute infection with noncytopathic BVDV. The ovaries of 5 BVDV sero-negative and virus-negative pubertal heifers were monitored daily for 4 consecutive estrous cycles. The position and diameter of all follicles (>5mm) and luteal structures were recorded. Daily plasma samples were collected to measure peripheral progesterone and estradiol levels. Each heifer was infected intranasally with noncytopathic BVDV following ovulation of the second estrous cycle. The maximum diameter and growth rate of dominant anovulatory and ovulatory follicles were significantly reduced following acute BVDV infection. Similarly, the number of subordinate follicles associated with both the anovulatory and ovulatory follicle was reduced following infection. There were no significant differences in other follicle or luteal dynamic parameters or in peripheral progesterone or estradiol levels. Ovarian follicular growth was different during the first 2 estrous cycles following acute infection with BVDV when compared with the 2 estrous cycles preceding infection. These differences may be important in explaining reduced fertility in herds with acute BVDV infection.",
author = "Grooms, {D. L.} and Brock, {K. V.} and Pate, {J. L.} and Day, {M. L.}",
note = "Funding Information: Bovine viral diarrhea virus (BVDV) has been associated with several reproductive problems in cattle, including poor fertility, early embryonic deaths, abortion and congenital anomalies. Little is known about the cause of poor fertility in cows acutely infected with BVDV. The purpose of this study was to identify changes in ovarian function following acute infection with noncytopathic BVDV. The ovaries of 5 BVDV sero-negative and virus-negative pubertal heifers were monitored daily for 4 consecutive estrous cycles. The position and diameter of all follicles (>5mm) and luteal structures were recorded. Daily plasma samples were collected to measure peripheral progesterone and estradiol levels. Each heifer was infected intranasally with noncytopathic BVDV following ovulation of the second estrous cycle. The maximum diameter and growth rate of dominant anovulatory and ovulatory follicles were significantly reduced following acute BVDV infection. Similarly, the number of subordinate follicles associated with both the anovulatory and ovulatory follicle was reduced following infection. There were no significant differences in other follicle or luteal dynamic parameters or in peripheral progesterone or estradiol levels. Ovarian follicular growth was different during the first 2 estrous cycles following acute infection with BVDV when compared with the 2 estrous cycles preceding infection. These differences may be important in explaining reduced fertility in herds with acute BVDV infection. {\textcopyright} 1998 by ElsevierS cience Inc. Key words: bovine viral diarrhea virus, follicular dynamics Acknowledgments This work was supported in part by the Cooperative State Research Service agreement No. 90-34116-5286 and state and federal funds appropriated to the Ohio Agricultural Research and Development Center. Manuscript # 68-97. a Current address Dept. of Large Animal Clinical Sciences, Michigan State Univeristy, bEast Lansing, MI. Correspondence and reprint requests: K.V. Brock, Dept. of Pathobiology, College of Veterinary Medicine, 264 Greene Hall, Auburn University, AL 36849-5519.",
year = "1998",
month = feb,
doi = "10.1016/S0093-691X(98)00010-7",
language = "English (US)",
volume = "49",
pages = "595--605",
journal = "Theriogenology",
issn = "0093-691X",
publisher = "Elsevier Inc.",
number = "3",
}
