TY - JOUR
T1 - Chapter 7 Biomarkers in the Study of Families of Children with Developmental Disabilities
AU - Seltzer, Marsha Mailick
AU - Abbeduto, Leonard
AU - Greenberg, Jan S.
AU - Almeida, David
AU - Hong, Jinkuk
AU - Witt, Whitney
N1 - Funding Information:
This research was supported by grants from the National Institute of Child Health and Human Development (R01HD024356 and R03HD048884, L. Abbeduto, PI; P30 HD03352, M. M. Seltzer, PI) and the National Institute on Aging (P01AG020166, C. D. Ryff, PI, and R01AG019239, D. Almeida, PI) to conduct a longitudinal follow-up of the MIDUS (Midlife in the US) investigation. The original MIDUS study was supported by the John D. and Catherine T. MacArthur Foundation Research Network on Successful Midlife Development. We also acknowledge the contributions of Jyoti Savla, Robert Stawski, and Julie Lounds Taylor to the research on parenting and cortisol.
PY - 2009
Y1 - 2009
N2 - Research during the past 20 years on families of children with developmental disabilities (DD) has yielded a rich body of knowledge about the risk and protective factors that result in profiles of family resilience versus vulnerability at various stages of the family life course. Virtually all of this research has been based on data collected from self-report or observational measures, and has examined family interactions, family relationships, and the psychosocial well-being of individual family members. The present chapter focuses on different sources of data, namely biomarkers, which have the potential to expand our understanding of the biological mechanisms by which the stress of parenting a child with developmental disabilities can take its toll on parents' physical and mental health. We focus on two examples: (1) variations in the FMR1 gene, FMRP, and FMR1 messenger RNA in mothers of children with fragile X syndrome and the association of these measures with maternal depression and anxiety and (2) profiles of cortisol in mothers of children with disabilities and the association of cortisol with daily measures of caregiving stress. These biomarkers extend past behavioral and psychosocial measures of family adaptations.
AB - Research during the past 20 years on families of children with developmental disabilities (DD) has yielded a rich body of knowledge about the risk and protective factors that result in profiles of family resilience versus vulnerability at various stages of the family life course. Virtually all of this research has been based on data collected from self-report or observational measures, and has examined family interactions, family relationships, and the psychosocial well-being of individual family members. The present chapter focuses on different sources of data, namely biomarkers, which have the potential to expand our understanding of the biological mechanisms by which the stress of parenting a child with developmental disabilities can take its toll on parents' physical and mental health. We focus on two examples: (1) variations in the FMR1 gene, FMRP, and FMR1 messenger RNA in mothers of children with fragile X syndrome and the association of these measures with maternal depression and anxiety and (2) profiles of cortisol in mothers of children with disabilities and the association of cortisol with daily measures of caregiving stress. These biomarkers extend past behavioral and psychosocial measures of family adaptations.
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U2 - 10.1016/S0074-7750(09)37007-X
DO - 10.1016/S0074-7750(09)37007-X
M3 - Review article
AN - SCOPUS:74249098211
SN - 0074-7750
VL - 37
SP - 213
EP - 249
JO - International Review of Research in Mental Retardation
JF - International Review of Research in Mental Retardation
IS - C
ER -
