TY - JOUR
T1 - Characterization of a daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus strain in a patient with endocarditis
AU - Julian, Kathleen
AU - Kosowska-Shick, Klaudia
AU - Whitener, Cynthia
AU - Roos, Martin
AU - Labischinski, Harald
AU - Rubio, Aileen
AU - Parent, Leslie
AU - Ednie, Lois
AU - Koeth, Laura
AU - Bogdanovich, Tatiana
AU - Appelbaum, Peter C.
PY - 2007/9
Y1 - 2007/9
N2 - We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA'S cell wall demonstrated a reduction in muramic acid O-acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene.
AB - We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA'S cell wall demonstrated a reduction in muramic acid O-acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene.
UR - https://www.scopus.com/pages/publications/35948935576
UR - https://www.scopus.com/pages/publications/35948935576#tab=citedBy
U2 - 10.1128/AAC.00559-07
DO - 10.1128/AAC.00559-07
M3 - Article
C2 - 17620372
AN - SCOPUS:35948935576
SN - 0066-4804
VL - 51
SP - 3445
EP - 3448
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 9
ER -