TY - JOUR
T1 - Characterization of dioxin exposure in residents of Chapaevsk, Russia
AU - Akhmedkhanov, Arslan
AU - Revich, Boris
AU - Adibi, Jennifer J.
AU - Zeilert, Vladimir
AU - Masten, Scott A.
AU - Patterson, Donald G.
AU - Needham, Larry L.
AU - Toniolo, Paolo
N1 - Funding Information:
Collection and analysis of human samples were supported through an agreement with the Environmental Toxicology Program of the US National Institute of Environmental Health Sciences and by Public Health Service Grants ES00260 and CA16087. Dioxin analyses were supported by interagency agreement Y1-ES-8062-02 between the National Institute of Environmental Health Sciences and the National Center for Environmental Health. This work was undertaken during the tenure of Dr. Paolo Toniolo from a Senior Visiting Scientist Award from the IARC ( Lyon, France ). The authors are grateful to the administration of the City of Chapaevsk for logistical support.
PY - 2002/11
Y1 - 2002/11
N2 - Since 1967, a chemical plant in the town of Chapaevsk (Samara province, Russia) has produced large amounts of chlorinated compounds and is suspected to be a major source of local environmental dioxin contamination. Dioxins have been detected in the local air, soil, drinking water, vegetables, and cow's milk. Human exposure to dioxins is suspected as a factor in the deteriorating local public health. In an effort to characterize nonoccupational dioxin exposure among local residents, during the summer of 1998, 24 volunteers were recruited to donate blood and to provide information about their residence, employment, demographics, medical history, and dietary habits. Selected polychlorinated dibenzodioxins, dibenzofurans, and coplanar biphenyls were measured in blood serum samples. The mean concentration of total dioxin World Health Organization toxic equivalents (WHO-TEQ98) based on polychlorinated dibenzo-paradioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (PCBs) was 61.2 (range 61.4 168.1) pg/g lipid. Subjects living in close proximity to the plant (less than 5 km) had significantly higher dioxin levels (mean WHO-TEQ98, 75.7 pg/g lipid), as compared to subjects living more than 5 km from the plant (mean WHO-TEQ98, 44.1 pg/g lipid) (P<0.04). Comparisons of the study results with available published data indicate that average blood dioxin levels were substantially higher in Chapaevsk residents than in nonoccupationally exposed populations of other parts of Russia, Europe, and North America. Chronic exposures of such magnitude may have appreciable adverse effects on public health.
AB - Since 1967, a chemical plant in the town of Chapaevsk (Samara province, Russia) has produced large amounts of chlorinated compounds and is suspected to be a major source of local environmental dioxin contamination. Dioxins have been detected in the local air, soil, drinking water, vegetables, and cow's milk. Human exposure to dioxins is suspected as a factor in the deteriorating local public health. In an effort to characterize nonoccupational dioxin exposure among local residents, during the summer of 1998, 24 volunteers were recruited to donate blood and to provide information about their residence, employment, demographics, medical history, and dietary habits. Selected polychlorinated dibenzodioxins, dibenzofurans, and coplanar biphenyls were measured in blood serum samples. The mean concentration of total dioxin World Health Organization toxic equivalents (WHO-TEQ98) based on polychlorinated dibenzo-paradioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (PCBs) was 61.2 (range 61.4 168.1) pg/g lipid. Subjects living in close proximity to the plant (less than 5 km) had significantly higher dioxin levels (mean WHO-TEQ98, 75.7 pg/g lipid), as compared to subjects living more than 5 km from the plant (mean WHO-TEQ98, 44.1 pg/g lipid) (P<0.04). Comparisons of the study results with available published data indicate that average blood dioxin levels were substantially higher in Chapaevsk residents than in nonoccupationally exposed populations of other parts of Russia, Europe, and North America. Chronic exposures of such magnitude may have appreciable adverse effects on public health.
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U2 - 10.1038/sj.jea.7500243
DO - 10.1038/sj.jea.7500243
M3 - Article
C2 - 12415489
AN - SCOPUS:0036871106
SN - 1053-4245
VL - 12
SP - 409
EP - 417
JO - Journal of Exposure Analysis and Environmental Epidemiology
JF - Journal of Exposure Analysis and Environmental Epidemiology
IS - 6
ER -