Characterization of nicotinamidases: Steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism

Keyphrases

• Catalytic Mechanism 100%
• Kinetic Parameters 100%
• Steady-state Kinetics 100%
• Nicotinamidase 100%
• Nicotinaldehydes 100%
• Class-wide 100%
• Nicotinic Acid 37%
• Caenorhabditis Elegans 25%
• Nicotinamide 25%
• S. Pneumoniae 25%
• Aldehydes 12%
• Kinetic Assay 12%
• Km Value 12%
• Kcat 12%
• Kinetic Analysis 12%
• Plasmodium Falciparum 12%
• Steady State 12%
• Archaebacteria 12%
• Carbonyl 12%
• Saccharomyces Cerevisiae 12%
• Lyme Disease 12%
• Competitive Inhibitor 12%
• Virulence 12%
• Eubacteria 12%
• Transition Metal Ions 12%
• Drosophila Melanogaster 12%
• Pneumonia 12%
• Invertebrates 12%
• Mycobacterium 12%
• Pathogenic Microorganisms 12%
• Protozoa 12%
• Metabolic Enzymes 12%
• Cerevisiae 12%
• Streptococcus Pneumoniae 12%
• Catalytic Residues 12%
• Organismal Aging 12%
• Structural Work 12%
• Human Malaria 12%
• Borrelia Burgdorferi 12%
• NAD+ Metabolism 12%
• Thioester Intermediate 12%
• Enzyme Binding 12%
• Oxyanion Hole 12%
• H218O 12%
• Efficient Catalyst 12%

Immunology and Microbiology

• Steady State 100%
• Kinetic Parameter 100%
• Infectious Agent 66%
• Caenorhabditis Elegans 66%
• Pneumococcus 66%
• Plasmodium falciparum 33%
• Archaeon 33%
• Saccharomyces cerevisiae 33%
• Mycobacteria 33%
• Protozoa 33%
• Lifespan 33%
• Drosophila Melanogaster 33%
• Kinetics 33%
• Competitive Inhibition 33%
• Streptococcus Pneumoniae 33%
• Hydrolysis 33%
• Turnover Number 33%
• Pathogenic Microbes 33%
• Borrelia burgdorferi 33%
• Enzyme Binding 33%
• Bacterium 33%

Biochemistry, Genetics and Molecular Biology

• Enzyme Binding 14%
• Oxyanion Hole 14%
• Bacterium 14%
• Borrelia burgdorferi 14%
• Mycobacteria 14%