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Characterization of Radical S-adenosylmethionine Enzymes and Intermediates in their Reactions by Continuous Wave and Pulse Electron Paramagnetic Resonance Spectroscopies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Radical S-adenosylmethionine (SAM) enzymes comprise an important and a versatile superfamily of enzymes. For more than a decade, a significant effort has been directed towards understanding these enzymes. Electron paramagnetic resonance spectroscopy has played a crucial role in such studies, helping to decipher intricate details about the identity of the active metallocofactors, their relations to the substrate(s) utilized and an understanding of the mechanisms of the enzymatic reactions. In this chapter we overview research milestones in the field of radical SAM enzymes achieved with the aid of EPR spectroscopy.

Original languageEnglish (US)
Title of host publicationBiological Magnetic Resonance
PublisherSpringer Publishing Company
Pages143-186
Number of pages44
DOIs
StatePublished - 2017

Publication series

NameBiological Magnetic Resonance
Volume33
ISSN (Print)0192-6020

All Science Journal Classification (ASJC) codes

  • Spectroscopy
  • Computer Science Applications

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