Characterization of the inflammatory features of central centrifugal cicatricial alopecia

Alexandra Flamm, Ata S. Moshiri, Fritzlaine Roche, Ginikanwa Onyekaba, Jennifer Nguyen, Alaina J. James, Susan Taylor, John T. Seykora

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia that primarily affects women of African descent. Although histopathological features of CCCA have been described, the pathophysiology of this disease remains unclear. To better understand the components of CCCA pathophysiology, we evaluated the composition of the inflammatory infiltrate, the distribution of Langerhans cells (LCs), and the relationship between fibrosis and perifollicular vessel distribution. Our data indicate that CCCA is associated with a CD4-predominant T-cell infiltrate with increased LCs extending into the lower hair follicle. Fibroplasia associated with follicular scarring displaces blood vessels away from the outer root sheath epithelium. These data indicate that CCCA is an inflammatory scarring alopecia with unique pathophysiologic features that differentiate it from other lymphocytic scarring processes.

Original languageEnglish (US)
Pages (from-to)530-534
Number of pages5
JournalJournal of Cutaneous Pathology
Issue number6
StatePublished - Jun 1 2020

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology


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