Abstract
Transplantation of normal bone marrow to mice with the Chediak Higashi syndrome (CHS) resulted in normal granulopoiesis and a reversal of their increased susceptibility to challenge with intravenous Candida albicans. These findings suggest that the leukocyte defect in CHS can be reversed by marrow transplantation and that the mechanism for increased susceptibility to infection in these animals is due to a bone marrow derived cellular defect. Because of similarities between murine and human CHS, bone marrow transplantation might be considered as a mode of therapy in selected cases of the human disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 555-559 |
| Number of pages | 5 |
| Journal | Blood |
| Volume | 47 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1976 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Biochemistry
- Immunology
- Hematology
- Cell Biology
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