Chemical and bio sensing using graphene-enhanced raman spectroscopy

Alexander Silver, Hikari Kitadai, He Liu, Tomotaroh Granzier-Nakajima, Mauricio Terrones, Xi Ling, Shengxi Huang

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Graphene is a two-dimensional (2D) material consisting of a single sheet of sp2hybridized carbon atoms laced in a hexagonal lattice, with potentially wide usage as a Raman enhancement substrate, also termed graphene-enhanced Raman scattering (GERS), making it ideal for sensing applications. GERS improves upon traditional surface-enhanced Raman scattering (SERS), combining its single-molecule sensitivity and spectral fingerprinting of molecules, and graphene’s simple processing and superior uniformity. This enables fast and highly sensitive detection of a wide variety of analytes. Accordingly, GERS has been investigated for a wide variety of sensing applications, including chemical- and bio-sensing. As a derivative of GERS, the use of two-dimensional materials other than graphene for Raman enhancement has emerged, which possess remarkably interesting properties and potential wider applications in combination with GERS. In this review, we first introduce various types of 2D materials, including graphene, MoS 2 , doped graphene, their properties, and synthesis. Then, we describe the principles of GERS and comprehensively explain how the GERS enhancement factors are influenced by molecular and 2D material properties. In the last section, we discuss the application of GERS in chemical- and bio-sensing, and the prospects of such a novel sensing method.

Original languageEnglish (US)
Article number516
Issue number4
StatePublished - Apr 2019

All Science Journal Classification (ASJC) codes

  • General Chemical Engineering
  • General Materials Science


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