TY - JOUR
T1 - Chemical characterization and disposition studies with 1, 2, 7, 8tetrabromodibenzofuran in the rat
AU - Kedderis, Lorrene Buckley
AU - Jackson, Joseph A.
AU - Patterson, Donald G.
AU - Grainger, James
AU - Diliberto, Janet J.
AU - Birnbaum, Linda S.
N1 - Funding Information:
The authors acknowledge thehelpful discussions and critical review of this work by Drs. James D. McKinney and Leo T. Burka. The authors appreciate the cooperation of Chemsyn Science Laboratories in theidentification of theradiolabeted TBDF andthank Cambridge Isotope Laboratories for providing the NMRspectrum of 2,3,7,8-TBDF. This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. These studies were supported by funds provided by the U.S. EPA CR817643 through theCenter for Environmental Medicine andLung Biology, University of North Carolina, Chapel Hill,N.C. The current address for Lorrene B. Kedderis is Research Triangle Institute, P.O.Box 12194, Research Triangle Park, NC27709-2194. Address correspondence to Linda S. Birnbaum, U.S. EPA,MD-66, Research Triangle Park, NC 27711.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Polybrominated dibenzopdioxins and dibenzofurans have been identified as potential environmental contaminants. The present studies were designed to characterize the chemical disposition of a tetrabrominated dibenzofuran. The isomerspecific pattern of 1, 2, 7, 8-tetrabromodibenzofuran (TBDF) was chemically characterized using highpressure liquid chromatography, gas chromatography/mass spectrometry, infrared absorption, and proton nuclear magnetic resonance techniques. The absorption, distribution, and elimination of 1, 2, 7, 8-[4, 6-3H]TBDF were examined in the rat following a single oral, dermal, or intravenous dose of 1 nmol/kg. The 1, 2, 7, 8-TBDF was rapidly excreted in the bile (-50% of the dose in 8 h). Likewise, over half of the administered dose was found in the feces and intestine contents 24 h after iv administration and in feces 72 h after oral administration. Thus, the halflife of 1, 2, 7, 8-TBDF is approximately I d. Major tissue depots included the.
AB - Polybrominated dibenzopdioxins and dibenzofurans have been identified as potential environmental contaminants. The present studies were designed to characterize the chemical disposition of a tetrabrominated dibenzofuran. The isomerspecific pattern of 1, 2, 7, 8-tetrabromodibenzofuran (TBDF) was chemically characterized using highpressure liquid chromatography, gas chromatography/mass spectrometry, infrared absorption, and proton nuclear magnetic resonance techniques. The absorption, distribution, and elimination of 1, 2, 7, 8-[4, 6-3H]TBDF were examined in the rat following a single oral, dermal, or intravenous dose of 1 nmol/kg. The 1, 2, 7, 8-TBDF was rapidly excreted in the bile (-50% of the dose in 8 h). Likewise, over half of the administered dose was found in the feces and intestine contents 24 h after iv administration and in feces 72 h after oral administration. Thus, the halflife of 1, 2, 7, 8-TBDF is approximately I d. Major tissue depots included the.
UR - https://www.scopus.com/pages/publications/0028012173
UR - https://www.scopus.com/pages/publications/0028012173#tab=citedBy
U2 - 10.1080/15287399409531826
DO - 10.1080/15287399409531826
M3 - Article
C2 - 8277526
AN - SCOPUS:0028012173
SN - 0098-4108
VL - 41
SP - 53
EP - 69
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
IS - 1
ER -