TY - JOUR
T1 - Chemical-shift-resolved 19FNMR spectroscopy between 13.5 and 135MHz
T2 - Overhauser-DNP-enhanced diagonal suppressed correlation spectroscopy
AU - George, Christy
AU - Chandrakumar, Narayanan
PY - 2014/8/4
Y1 - 2014/8/4
N2 - Overhauser-DNP-enhanced homonuclear 2D 19F correlation spectroscopy with diagonal suppression is presented for small molecules in the solution state at moderate fields. Multi-frequency, multi-radical studies demonstrate that these relatively low-field experiments may be operated with sensitivity rivalling that of standard 200-1000MHz NMR spectroscopy. Structural information is accessible without a sensitivity penalty, and diagonal suppressed 2D NMR correlations emerge despite the general lack of multiplet resolution in the 1D ODNP spectra. This powerful general approach avoids the rather stiff excitation, detection, and other special requirements of high-field 19FNMR spectroscopy.
AB - Overhauser-DNP-enhanced homonuclear 2D 19F correlation spectroscopy with diagonal suppression is presented for small molecules in the solution state at moderate fields. Multi-frequency, multi-radical studies demonstrate that these relatively low-field experiments may be operated with sensitivity rivalling that of standard 200-1000MHz NMR spectroscopy. Structural information is accessible without a sensitivity penalty, and diagonal suppressed 2D NMR correlations emerge despite the general lack of multiplet resolution in the 1D ODNP spectra. This powerful general approach avoids the rather stiff excitation, detection, and other special requirements of high-field 19FNMR spectroscopy.
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U2 - 10.1002/anie.201402320
DO - 10.1002/anie.201402320
M3 - Article
AN - SCOPUS:84905396468
SN - 1433-7851
VL - 53
SP - 8441
EP - 8444
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 32
ER -