Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein

Manjunath Hegde; Derek L. Englert; Shanna Schrock; William B. Cohn; Christian Vogt; Thomas K. Wood; Michael D. Manson; Arul Jayaraman

doi:10.1128/JB.01196-10

Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein

Manjunath Hegde, Derek L. Englert, Shanna Schrock, William B. Cohn, Christian Vogt, Thomas K. Wood, Michael D. Manson, Arul Jayaraman

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

AI-2 is an autoinducer made by many bacteria. LsrB binds AI-2 in the periplasm, and Tsr is the L-serine chemoreceptor. We show that AI-2 strongly attracts Escherichia coli. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm.

Original language	English (US)
Pages (from-to)	768-773
Number of pages	6
Journal	Journal of bacteriology
Volume	193
Issue number	3
DOIs	https://doi.org/10.1128/JB.01196-10
State	Published - Feb 2011

All Science Journal Classification (ASJC) codes

Microbiology
Molecular Biology

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abstract = "AI-2 is an autoinducer made by many bacteria. LsrB binds AI-2 in the periplasm, and Tsr is the L-serine chemoreceptor. We show that AI-2 strongly attracts Escherichia coli. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm.",

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AU - Englert, Derek L.

AU - Schrock, Shanna

AU - Cohn, William B.

AU - Vogt, Christian

AU - Wood, Thomas K.

AU - Manson, Michael D.

AU - Jayaraman, Arul

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AB - AI-2 is an autoinducer made by many bacteria. LsrB binds AI-2 in the periplasm, and Tsr is the L-serine chemoreceptor. We show that AI-2 strongly attracts Escherichia coli. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm.

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Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein

Abstract

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