TY - JOUR
T1 - Childhood Obesity and Autonomic Dysfunction
T2 - Risk for Cardiac Morbidity and Mortality
AU - Liao, Duanping
AU - Rodríguez-Colón, Sol M.
AU - He, Fan
AU - Bixler, Edward O.
N1 - Funding Information:
National Institutes of Health (NIH) grants: 1 R01 HL 097165, R01 HL63772, R21HL087858, and the Penn State CTSI Grant UL Tr000127. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2014/9/11
Y1 - 2014/9/11
N2 - The epidemic of childhood obesity is becoming a major predictor for risk of cardiovascular diseases (CVD) and mortality during adulthood. Alterations in the morphology of the heart due to obesity could be a predictor for the dysfunction of cardiac autonomic modulation (CAM). A number of epidemiologic studies have evaluated the effect of obesity and CAM in children, finding that obesity impaired the balance of CAM toward a sympathetic overflow and reduced parasympathetic modulation, a significant predictor of CVD morbidity and mortality in adults. Lifestyle modifications, for example long-term exercise programs, have been shown to improve CAM in the obese. This review discusses the recent evidence on childhood and adolescent obesity and its impact on CAM, as well as how early lifestyle changes could help improve CAM, which may in turn reduce the burden of CVD in adults.
AB - The epidemic of childhood obesity is becoming a major predictor for risk of cardiovascular diseases (CVD) and mortality during adulthood. Alterations in the morphology of the heart due to obesity could be a predictor for the dysfunction of cardiac autonomic modulation (CAM). A number of epidemiologic studies have evaluated the effect of obesity and CAM in children, finding that obesity impaired the balance of CAM toward a sympathetic overflow and reduced parasympathetic modulation, a significant predictor of CVD morbidity and mortality in adults. Lifestyle modifications, for example long-term exercise programs, have been shown to improve CAM in the obese. This review discusses the recent evidence on childhood and adolescent obesity and its impact on CAM, as well as how early lifestyle changes could help improve CAM, which may in turn reduce the burden of CVD in adults.
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U2 - 10.1007/s11936-014-0342-1
DO - 10.1007/s11936-014-0342-1
M3 - Review article
AN - SCOPUS:85027947085
SN - 1092-8464
VL - 16
JO - Current Treatment Options in Cardiovascular Medicine
JF - Current Treatment Options in Cardiovascular Medicine
IS - 10
M1 - 342
ER -