Children with organic growth hormone deficiency have elevated cortisol responses to stimuli

Jordan W. Finkelstein, Daniela E. Rusovici, Edna Green, Stephen Foreman, Howard E. Kulin, M. Rose D'Arcangelo, Robertas Kemezys

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The aim of this study was to investigate hypothalamic-pituitary-adrenal (HPA) function in children with GH deficiency. Ninety-four patients were evaluated for GH deficiency and cortisol (F) deficiency using clinical criteria and L-dopa and insulin-induced hypoglycemia stimulation tests. They were assigned to three diagnostic groups: organic GH deficient (OGHD), idiopathic GH deficient (IGHD), and not GH-deficient (NGHD). Time series, cross-sectional, regression analysis revealed statistically significantly elevated F [>828 nmol/L (30 μg/dL)] in the OGHD group vs. the NGHD group. The value for F in the IGHD group was not different from the NGHD group. This finding suggests that dysregulation of the HPA axis is present in most children with OGH deficiency and significantly less often in children with IGH deficiency or without GH deficiency. Anatomical disruption of the control pathways for the HPA axis or stress may cause the dysregulation.

Original languageEnglish (US)
Pages (from-to)2854-2856
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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