TY - JOUR
T1 - Chlorinated Derivatives of Dibenzo-p-dioxin and Related Compounds for Use as Reference Compounds in Method Development and Environmental Toxicology
AU - Barnhart, Elizabeth R.
AU - Patterson, Donald G.
AU - Ashley, David L.
AU - Maggio, Vince
AU - Alley, Cynthia C.
AU - Alexander, Louis R.
AU - MacBride, J. Hugh
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - Analytical reference standards are not readily available for many of the chlorinated aromatic compounds that have been Identified as environmental contaminants. We used sulfuryl chloride preparations to chlorinate aromatic compounds thereby obtaining the congeners needed as reference standards for gas chromatography/mass spectrometry analyses. We used commercially available vialed reagents and small vessels (reaction vials) for the production of milligram quantities of the toxicants. With biphenyl, dibenzofuran, and dibenzo-p-dioxin, the major products were polychloro derivatives of the respective starting material. With biphenylene and pyrene, polychloro-substltutlon products and addition products were also obtained. Polar constituents of the reaction mixtures were removed on silica gel, and the products were separated by high-performance liquid chromatography and identified by gas chromatography/mass spectrometry, nuclear magnetic resonance spectrometry, and Infrared spectrometry.
AB - Analytical reference standards are not readily available for many of the chlorinated aromatic compounds that have been Identified as environmental contaminants. We used sulfuryl chloride preparations to chlorinate aromatic compounds thereby obtaining the congeners needed as reference standards for gas chromatography/mass spectrometry analyses. We used commercially available vialed reagents and small vessels (reaction vials) for the production of milligram quantities of the toxicants. With biphenyl, dibenzofuran, and dibenzo-p-dioxin, the major products were polychloro derivatives of the respective starting material. With biphenylene and pyrene, polychloro-substltutlon products and addition products were also obtained. Polar constituents of the reaction mixtures were removed on silica gel, and the products were separated by high-performance liquid chromatography and identified by gas chromatography/mass spectrometry, nuclear magnetic resonance spectrometry, and Infrared spectrometry.
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U2 - 10.1021/ac00145a008
DO - 10.1021/ac00145a008
M3 - Article
C2 - 3674442
AN - SCOPUS:0023656181
SN - 0003-2700
VL - 59
SP - 2248
EP - 2252
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 18
ER -