Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance.

D. Fallows; R. B. Kent; D. L. Nelson; J. R. Emanuel; R. Levenson; D. E. Housman

doi:10.1128/MCB.7.8.2985

Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance.

D. Fallows, R. B. Kent, D. L. Nelson, J. R. Emanuel, R. Levenson, D. E. Housman

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19 Scopus citations

Abstract

We transferred murine NIH 3T3 metaphase chromosomes into monkey CV-1 cells to investigate the different ouabain sensitivities of rodent and primate cells. In 16 ouabain-resistant transferents, the mouse Na,K-ATPase alpha 1 subunit gene was detected, suggesting that structural differences between the rodent and primate alpha 1 subunits determine the different ouabain sensitivities.

Original language	English (US)
Pages (from-to)	2985-2987
Number of pages	3
Journal	Molecular and cellular biology
Volume	7
Issue number	8
DOIs	https://doi.org/10.1128/MCB.7.8.2985
State	Published - Aug 1987

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1128/MCB.7.8.2985

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abstract = "We transferred murine NIH 3T3 metaphase chromosomes into monkey CV-1 cells to investigate the different ouabain sensitivities of rodent and primate cells. In 16 ouabain-resistant transferents, the mouse Na,K-ATPase alpha 1 subunit gene was detected, suggesting that structural differences between the rodent and primate alpha 1 subunits determine the different ouabain sensitivities.",

author = "D. Fallows and Kent, {R. B.} and Nelson, {D. L.} and Emanuel, {J. R.} and R. Levenson and Housman, {D. E.}",

year = "1987",

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AU - Kent, R. B.

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AU - Emanuel, J. R.

AU - Levenson, R.

AU - Housman, D. E.

PY - 1987/8

Y1 - 1987/8

N2 - We transferred murine NIH 3T3 metaphase chromosomes into monkey CV-1 cells to investigate the different ouabain sensitivities of rodent and primate cells. In 16 ouabain-resistant transferents, the mouse Na,K-ATPase alpha 1 subunit gene was detected, suggesting that structural differences between the rodent and primate alpha 1 subunits determine the different ouabain sensitivities.

AB - We transferred murine NIH 3T3 metaphase chromosomes into monkey CV-1 cells to investigate the different ouabain sensitivities of rodent and primate cells. In 16 ouabain-resistant transferents, the mouse Na,K-ATPase alpha 1 subunit gene was detected, suggesting that structural differences between the rodent and primate alpha 1 subunits determine the different ouabain sensitivities.

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Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance.

Abstract

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