Chronic alcohol alters rewarded behaviors and striatal plasticity

Lauren DePoy, Rachel Daut, Tara Wright, Marguerite Camp, Nicole Crowley, Bianca Noronha, David Lovinger, Andrew Holmes

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16-bout) CIE on DLS plasticity and DLS-mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long-term depression after CIE. CIE increased two-bottle choice drinking and impaired Pavlovian-to-instrumental transfer but not discriminated approach. These data suggest prolonged CIE impaired DLS plasticity, to produce associated changes in drinking and cue-controlled reward-seeking. Given recent evidence that less-prolonged CIE can promote certain dorsal striatal-mediated behaviors, CIE may drive chronicity-dependent adaptations in corticostriatal systems regulating behavior.

Original languageEnglish (US)
Pages (from-to)345-348
Number of pages4
JournalAddiction Biology
Issue number2
StatePublished - Mar 1 2015

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health


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