Chronic alcohol alters rewarded behaviors and striatal plasticity

Lauren DePoy; Rachel Daut; Tara Wright; Marguerite Camp; Nicole Crowley; Bianca Noronha; David Lovinger; Andrew Holmes

doi:10.1111/adb.12131

Chronic alcohol alters rewarded behaviors and striatal plasticity

Lauren DePoy, Rachel Daut, Tara Wright, Marguerite Camp, Nicole Crowley, Bianca Noronha, David Lovinger, Andrew Holmes

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16-bout) CIE on DLS plasticity and DLS-mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long-term depression after CIE. CIE increased two-bottle choice drinking and impaired Pavlovian-to-instrumental transfer but not discriminated approach. These data suggest prolonged CIE impaired DLS plasticity, to produce associated changes in drinking and cue-controlled reward-seeking. Given recent evidence that less-prolonged CIE can promote certain dorsal striatal-mediated behaviors, CIE may drive chronicity-dependent adaptations in corticostriatal systems regulating behavior.

Original language	English (US)
Pages (from-to)	345-348
Number of pages	4
Journal	Addiction Biology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1111/adb.12131
State	Published - Mar 1 2015

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Pharmacology
Psychiatry and Mental health

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10.1111/adb.12131

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title = "Chronic alcohol alters rewarded behaviors and striatal plasticity",

abstract = "Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16-bout) CIE on DLS plasticity and DLS-mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long-term depression after CIE. CIE increased two-bottle choice drinking and impaired Pavlovian-to-instrumental transfer but not discriminated approach. These data suggest prolonged CIE impaired DLS plasticity, to produce associated changes in drinking and cue-controlled reward-seeking. Given recent evidence that less-prolonged CIE can promote certain dorsal striatal-mediated behaviors, CIE may drive chronicity-dependent adaptations in corticostriatal systems regulating behavior.",

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T1 - Chronic alcohol alters rewarded behaviors and striatal plasticity

AU - DePoy, Lauren

AU - Daut, Rachel

AU - Wright, Tara

AU - Camp, Marguerite

AU - Crowley, Nicole

AU - Noronha, Bianca

AU - Lovinger, David

AU - Holmes, Andrew

PY - 2015/3/1

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N2 - Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16-bout) CIE on DLS plasticity and DLS-mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long-term depression after CIE. CIE increased two-bottle choice drinking and impaired Pavlovian-to-instrumental transfer but not discriminated approach. These data suggest prolonged CIE impaired DLS plasticity, to produce associated changes in drinking and cue-controlled reward-seeking. Given recent evidence that less-prolonged CIE can promote certain dorsal striatal-mediated behaviors, CIE may drive chronicity-dependent adaptations in corticostriatal systems regulating behavior.

AB - Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16-bout) CIE on DLS plasticity and DLS-mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long-term depression after CIE. CIE increased two-bottle choice drinking and impaired Pavlovian-to-instrumental transfer but not discriminated approach. These data suggest prolonged CIE impaired DLS plasticity, to produce associated changes in drinking and cue-controlled reward-seeking. Given recent evidence that less-prolonged CIE can promote certain dorsal striatal-mediated behaviors, CIE may drive chronicity-dependent adaptations in corticostriatal systems regulating behavior.

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Chronic alcohol alters rewarded behaviors and striatal plasticity

Abstract

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