Chronic Insomnia and the Stress System

Maria Basta, George P. Chrousos, Antonio Vela-Bueno, Alexandros N. Vgontzas

Research output: Contribution to journalReview articlepeer-review

207 Scopus citations


In insomnia, which is a very common sleep disorder, objective sleep measures, EEG activity, physiologic findings, HPA axis activity, and inflammation markers suggest that it is not a state of sleep loss, but a disorder of hyperarousal present both during the night and the daytime. Several psychological and physiological factors contribute to the onset and perpetuation of insomnia, such as anxious-ruminative personality traits, stressful events, age-related sleep homeostasis weakening mechanisms, menopause, and biologic-genetic diathesis of CNS hyperarousal. The therapeutic approach in insomnia should be multidimensional, reducing the overall emotional and physiologic hyperarousal and its underlying factors present throughout the 24-hour sleep/wake period.

Original languageEnglish (US)
Pages (from-to)279-291
Number of pages13
JournalSleep Medicine Clinics
Issue number2
StatePublished - Jun 2007

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health


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