Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes A Case Report

Karen L. de Mesy Bentley, Ashlee MacDonald, Edward M. Schwarz, Irvin Oh

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Case: A patient presenting with an infected diabetic foot ulcer and Staphylococcus aureus chronic osteomyelitis was studied to validate the clinical importance of bacterial colonization of osteocytic-canalicular networks, as we recently reported in a mouse model. We utilized transmission electron microscopy to describe the deformation of S. aureus, from round cocci to rod-shaped bacteria, in the submicron osteocytic-canalicular networks of amputated bone tissue. Conclusion: To our knowledge, this is the first evidence of S. aureus deformation and invasion of the osteocyticcanalicular system in human bone, which supports a new mechanism of persistence in the pathogenesis of chronic osteomyelitis.

Original languageEnglish (US)
Article numbere8
JournalJBJS case connector
Issue number1
StatePublished - Mar 1 2018

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

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