Chronic unpredictable stress during adolescence causes long-term anxiety

L. E. Chaby; S. A. Cavigelli; A. M. Hirrlinger; M. J. Caruso; V. A. Braithwaite

doi:10.1016/j.bbr.2014.09.003

Chronic unpredictable stress during adolescence causes long-term anxiety

L. E. Chaby, S. A. Cavigelli, A. M. Hirrlinger, M. J. Caruso, V. A. Braithwaite

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Exposure to stress during adolescence can cause long-term changes in behavior and cognition. Anxiety diagnoses rise during adolescence and are increased by adverse experiences. Currently, it is unknown how long stress during adolescence alters anxiety in adulthood. We found that rats exposed to chronic unpredictable stress during adolescence expressed altered behavior 6.5 months later; showing increased anxiety in a feeding test in a novel environment. Although behavioral changes indicative of anxiety were detected in late adulthood, the basal levels of fecal corticoid metabolites in prior-stressed rats did not differ from unstressed, control rats.

Original language	English (US)
Pages (from-to)	492-495
Number of pages	4
Journal	Behavioural Brain Research
Volume	278
DOIs	https://doi.org/10.1016/j.bbr.2014.09.003
State	Published - Feb 1 2015

All Science Journal Classification (ASJC) codes

Behavioral Neuroscience

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10.1016/j.bbr.2014.09.003

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abstract = "Exposure to stress during adolescence can cause long-term changes in behavior and cognition. Anxiety diagnoses rise during adolescence and are increased by adverse experiences. Currently, it is unknown how long stress during adolescence alters anxiety in adulthood. We found that rats exposed to chronic unpredictable stress during adolescence expressed altered behavior 6.5 months later; showing increased anxiety in a feeding test in a novel environment. Although behavioral changes indicative of anxiety were detected in late adulthood, the basal levels of fecal corticoid metabolites in prior-stressed rats did not differ from unstressed, control rats.",

author = "Chaby, {L. E.} and Cavigelli, {S. A.} and Hirrlinger, {A. M.} and Caruso, {M. J.} and Braithwaite, {V. A.}",

note = "Funding Information: We thank the Huck Institute of the Life Sciences and the Eberly College of Science for support. This project was also funded, in part, under a grant with the Pennsylvania Department of Health using Tobacco CURE Funds . The Department specifically disclaims responsibility for any analyses, interpretations or conclusions. We would also like to thank the members of the Braithwaite group, with a special thanks to Carl Hirrlinger for his patience and assistance. Publisher Copyright: {\textcopyright} 2014 Elsevier B.V. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Cavigelli, S. A.

AU - Hirrlinger, A. M.

AU - Caruso, M. J.

AU - Braithwaite, V. A.

N1 - Funding Information: We thank the Huck Institute of the Life Sciences and the Eberly College of Science for support. This project was also funded, in part, under a grant with the Pennsylvania Department of Health using Tobacco CURE Funds . The Department specifically disclaims responsibility for any analyses, interpretations or conclusions. We would also like to thank the members of the Braithwaite group, with a special thanks to Carl Hirrlinger for his patience and assistance. Publisher Copyright: © 2014 Elsevier B.V. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Exposure to stress during adolescence can cause long-term changes in behavior and cognition. Anxiety diagnoses rise during adolescence and are increased by adverse experiences. Currently, it is unknown how long stress during adolescence alters anxiety in adulthood. We found that rats exposed to chronic unpredictable stress during adolescence expressed altered behavior 6.5 months later; showing increased anxiety in a feeding test in a novel environment. Although behavioral changes indicative of anxiety were detected in late adulthood, the basal levels of fecal corticoid metabolites in prior-stressed rats did not differ from unstressed, control rats.

AB - Exposure to stress during adolescence can cause long-term changes in behavior and cognition. Anxiety diagnoses rise during adolescence and are increased by adverse experiences. Currently, it is unknown how long stress during adolescence alters anxiety in adulthood. We found that rats exposed to chronic unpredictable stress during adolescence expressed altered behavior 6.5 months later; showing increased anxiety in a feeding test in a novel environment. Although behavioral changes indicative of anxiety were detected in late adulthood, the basal levels of fecal corticoid metabolites in prior-stressed rats did not differ from unstressed, control rats.

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Chronic unpredictable stress during adolescence causes long-term anxiety

Abstract

All Science Journal Classification (ASJC) codes

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