Chronic unpredictable stress during adolescence causes long-term anxiety

L. E. Chaby, S. A. Cavigelli, A. M. Hirrlinger, M. J. Caruso, V. A. Braithwaite

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Exposure to stress during adolescence can cause long-term changes in behavior and cognition. Anxiety diagnoses rise during adolescence and are increased by adverse experiences. Currently, it is unknown how long stress during adolescence alters anxiety in adulthood. We found that rats exposed to chronic unpredictable stress during adolescence expressed altered behavior 6.5 months later; showing increased anxiety in a feeding test in a novel environment. Although behavioral changes indicative of anxiety were detected in late adulthood, the basal levels of fecal corticoid metabolites in prior-stressed rats did not differ from unstressed, control rats.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalBehavioural Brain Research
StatePublished - Feb 1 2015

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience


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