TY - GEN
T1 - Circulating tumor cell capture from whole blood by parylene filter devices
AU - Zheng, Siyang
AU - Tai, Yu Chong
AU - Lin, Henry
AU - Balic, Marija
AU - Datar, Ram
AU - Cote, Richard J.
PY - 2005
Y1 - 2005
N2 - We report here design, fabrication and testing of parylene membrane filter device for capturing circulating tumor cell (CTC) from undiluted human peripheral blood. To our knowledge, this is the first micromachined membrane filter used for rare CTC detection. Even without much optimization, the device already demonstrates 89% recovery and 9 log10 enrichment and out-performs most current methods used in the field [1]. Moreover, less than 10 minutes are required for each sample separation, compared to current multistep processing needing > 1 hour.
AB - We report here design, fabrication and testing of parylene membrane filter device for capturing circulating tumor cell (CTC) from undiluted human peripheral blood. To our knowledge, this is the first micromachined membrane filter used for rare CTC detection. Even without much optimization, the device already demonstrates 89% recovery and 9 log10 enrichment and out-performs most current methods used in the field [1]. Moreover, less than 10 minutes are required for each sample separation, compared to current multistep processing needing > 1 hour.
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M3 - Conference contribution
AN - SCOPUS:84902439749
SN - 0974361119
SN - 9780974361116
T3 - Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 874
EP - 876
BT - Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
PB - Transducer Research Foundation
T2 - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
Y2 - 9 October 2005 through 13 October 2005
ER -