CIS-platinum ototoxicity: Clinical experience and temporal bone histopathology

Melvin Strauss; Javad Towfighi; Allan Lipton; Sherman Lord; Harold Harvey; Barbara Brown

doi:10.1288/00005537-198312000-00007

CIS-platinum ototoxicity: Clinical experience and temporal bone histopathology

Melvin Strauss, Javad Towfighi, Allan Lipton, Sherman Lord, Harold Harvey, Barbara Brown

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Abstract

A clinical and pathologic study of cis-plntinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency. Temporal bones from a 9-year-old with frontal lobe astrocytoma and with cis-platinum ototoxicity were studied with routine and special techniques to elucidate oto and neurotoxicity. Degenerative changes in the outer hair cells in the lower turns of the cochlea, in the spiral ganglion, and cochlear nerve were the most striking findings.

Original language	English (US)
Pages (from-to)	1554-1559
Number of pages	6
Journal	Laryngoscope
Volume	93
Issue number	12
DOIs	https://doi.org/10.1288/00005537-198312000-00007
State	Published - Dec 1983

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Otorhinolaryngology

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10.1288/00005537-198312000-00007

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abstract = "A clinical and pathologic study of cis-plntinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency. Temporal bones from a 9-year-old with frontal lobe astrocytoma and with cis-platinum ototoxicity were studied with routine and special techniques to elucidate oto and neurotoxicity. Degenerative changes in the outer hair cells in the lower turns of the cochlea, in the spiral ganglion, and cochlear nerve were the most striking findings.",

author = "Melvin Strauss and Javad Towfighi and Allan Lipton and Sherman Lord and Harold Harvey and Barbara Brown",

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T1 - CIS-platinum ototoxicity

T2 - Clinical experience and temporal bone histopathology

AU - Strauss, Melvin

AU - Towfighi, Javad

AU - Lipton, Allan

AU - Lord, Sherman

AU - Harvey, Harold

AU - Brown, Barbara

PY - 1983/12

Y1 - 1983/12

N2 - A clinical and pathologic study of cis-plntinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency. Temporal bones from a 9-year-old with frontal lobe astrocytoma and with cis-platinum ototoxicity were studied with routine and special techniques to elucidate oto and neurotoxicity. Degenerative changes in the outer hair cells in the lower turns of the cochlea, in the spiral ganglion, and cochlear nerve were the most striking findings.

AB - A clinical and pathologic study of cis-plntinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency. Temporal bones from a 9-year-old with frontal lobe astrocytoma and with cis-platinum ototoxicity were studied with routine and special techniques to elucidate oto and neurotoxicity. Degenerative changes in the outer hair cells in the lower turns of the cochlea, in the spiral ganglion, and cochlear nerve were the most striking findings.

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CIS-platinum ototoxicity: Clinical experience and temporal bone histopathology

Abstract

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