CIS-platinum ototoxicity: Clinical experience and temporal bone histopathology

Melvin Strauss, Javad Towfighi, Allan Lipton, Sherman Lord, Harold Harvey, Barbara Brown

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


A clinical and pathologic study of cis-plntinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency. Temporal bones from a 9-year-old with frontal lobe astrocytoma and with cis-platinum ototoxicity were studied with routine and special techniques to elucidate oto and neurotoxicity. Degenerative changes in the outer hair cells in the lower turns of the cochlea, in the spiral ganglion, and cochlear nerve were the most striking findings.

Original languageEnglish (US)
Pages (from-to)1554-1559
Number of pages6
Issue number12
StatePublished - Dec 1983

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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