Abstract
A clinical and pathologic study of cis-plntinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency. Temporal bones from a 9-year-old with frontal lobe astrocytoma and with cis-platinum ototoxicity were studied with routine and special techniques to elucidate oto and neurotoxicity. Degenerative changes in the outer hair cells in the lower turns of the cochlea, in the spiral ganglion, and cochlear nerve were the most striking findings.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1554-1559 |
| Number of pages | 6 |
| Journal | Laryngoscope |
| Volume | 93 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1983 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Otorhinolaryngology
Fingerprint
Dive into the research topics of 'CIS-platinum ototoxicity: Clinical experience and temporal bone histopathology'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver