Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration

Dawei Sun; Yuhui Chen; Richard T. Tran; Song Xu; Denghui Xie; Chunhong Jia; Yuchen Wang; Ying Guo; Zhongmin Zhang; Jinshan Guo; Jian Yang; Dadi Jin; Xiaochun Bai

doi:10.1038/srep06912

Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration

Dawei Sun, Yuhui Chen, Richard T. Tran, Song Xu, Denghui Xie, Chunhong Jia, Yuchen Wang, Ying Guo, Zhongmin Zhang, Jinshan Guo, Jian Yang, Dadi Jin, Xiaochun Bai

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Abstract

Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-% HA with 70% porosity) were used as bare implants without the addition of growth factors or cells to renovate 4â€...mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness, and angiogenesis when compared to the control groups at 1, 3, and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic, and off-shelf-available options in the repair of orthopedic defects.

Original language	English (US)
Article number	6912
Journal	Scientific reports
Volume	4
DOIs	https://doi.org/10.1038/srep06912
State	Published - Nov 5 2014

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@article{d80a23708f3a4242ba60da7ca4d11881,

title = "Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration",

abstract = "Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-% HA with 70% porosity) were used as bare implants without the addition of growth factors or cells to renovate 4{\^a}€...mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness, and angiogenesis when compared to the control groups at 1, 3, and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic, and off-shelf-available options in the repair of orthopedic defects.",

author = "Dawei Sun and Yuhui Chen and Tran, {Richard T.} and Song Xu and Denghui Xie and Chunhong Jia and Yuchen Wang and Ying Guo and Zhongmin Zhang and Jinshan Guo and Jian Yang and Dadi Jin and Xiaochun Bai",

note = "Funding Information: This collaborative work was supported in part by National Natural Sciences Foundation of China (31370987, 31271271 and 31228007), GDHVPS (2011) Program for Changjiang Scholars and Innovative Research Team in University (IRT1142), U.S. National Institutes of Health (NIH) Awards (NIBIB EB012575, NCI CA182670, NHLBI HL118498), and U.S. National Science Foundation (NSF) Awards (DMR1313553, CMMI 1266116). Publisher Copyright: {\textcopyright} 2014, Nature Publishing Group. All rights reserved.",

year = "2014",

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day = "5",

doi = "10.1038/srep06912",

language = "English (US)",

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AU - Sun, Dawei

AU - Chen, Yuhui

AU - Tran, Richard T.

AU - Xu, Song

AU - Xie, Denghui

AU - Jia, Chunhong

AU - Wang, Yuchen

AU - Guo, Ying

AU - Zhang, Zhongmin

AU - Guo, Jinshan

AU - Yang, Jian

AU - Jin, Dadi

AU - Bai, Xiaochun

N1 - Funding Information: This collaborative work was supported in part by National Natural Sciences Foundation of China (31370987, 31271271 and 31228007), GDHVPS (2011) Program for Changjiang Scholars and Innovative Research Team in University (IRT1142), U.S. National Institutes of Health (NIH) Awards (NIBIB EB012575, NCI CA182670, NHLBI HL118498), and U.S. National Science Foundation (NSF) Awards (DMR1313553, CMMI 1266116). Publisher Copyright: © 2014, Nature Publishing Group. All rights reserved.

PY - 2014/11/5

Y1 - 2014/11/5

N2 - Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-% HA with 70% porosity) were used as bare implants without the addition of growth factors or cells to renovate 4â€...mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness, and angiogenesis when compared to the control groups at 1, 3, and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic, and off-shelf-available options in the repair of orthopedic defects.

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Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration

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