Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration

Dawei Sun; Yuhui Chen; Richard T. Tran; Song Xu; Denghui Xie; Chunhong Jia; Yuchen Wang; Ying Guo; Zhongmin Zhang; Jinshan Guo; Jian Yang; Dadi Jin; Xiaochun Bai

doi:10.1038/srep06912

Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration

Dawei Sun
, Yuhui Chen
, Richard T. Tran
, Song Xu
, Denghui Xie
, Chunhong Jia
, Yuchen Wang
, Ying Guo
, Zhongmin Zhang
, Jinshan Guo
, Jian Yang
, Dadi Jin
, Xiaochun Bai

Materials Research Institute (MRI)

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-% HA with 70% porosity) were used as bare implants without the addition of growth factors or cells to renovate 4â€...mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness, and angiogenesis when compared to the control groups at 1, 3, and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic, and off-shelf-available options in the repair of orthopedic defects.

Original language	English (US)
Article number	6912
Journal	Scientific reports
Volume	4
DOIs	https://doi.org/10.1038/srep06912
State	Published - Nov 5 2014

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title = "Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration",

abstract = "Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-\% HA with 70\% porosity) were used as bare implants without the addition of growth factors or cells to renovate 4{\^a}€...mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness, and angiogenesis when compared to the control groups at 1, 3, and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic, and off-shelf-available options in the repair of orthopedic defects.",

author = "Dawei Sun and Yuhui Chen and Tran, \{Richard T.\} and Song Xu and Denghui Xie and Chunhong Jia and Yuchen Wang and Ying Guo and Zhongmin Zhang and Jinshan Guo and Jian Yang and Dadi Jin and Xiaochun Bai",

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AU - Sun, Dawei

AU - Chen, Yuhui

AU - Tran, Richard T.

AU - Xu, Song

AU - Xie, Denghui

AU - Jia, Chunhong

AU - Wang, Yuchen

AU - Guo, Ying

AU - Zhang, Zhongmin

AU - Guo, Jinshan

AU - Yang, Jian

AU - Jin, Dadi

AU - Bai, Xiaochun

PY - 2014/11/5

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AB - Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-% HA with 70% porosity) were used as bare implants without the addition of growth factors or cells to renovate 4â€...mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness, and angiogenesis when compared to the control groups at 1, 3, and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic, and off-shelf-available options in the repair of orthopedic defects.

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Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration

Abstract

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