Classification of Protein Function

Arthur M. Lesk, Helen Parkinson, James C. Whisstock

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Annotation of a genome requires assignment of functions to gene products, in most cases on the basis of amino acid sequence alone. The goal of structural genomics projects is to make three dimensional information available, which is invaluable in assessing inferences from amino acid sequences. Nevertheless, prediction of protein function, even if sequence and structure are known, is in many cases a difficult problem. Comparative genomics and patterns of interaction sometimes provide essential clues. Some methods provide reasonable guesses at function, but none is foolproof. An underlying problem is that function is in many cases an ill defined concept. In this article we review the state of the art in function prediction.

Original languageEnglish (US)
Title of host publicationDatabase Annotation in Molecular Biology
Subtitle of host publicationPrinciples and Practice
Number of pages17
ISBN (Electronic)9780470012420
ISBN (Print)0470856815, 9780470856819
StatePublished - Jun 8 2005

All Science Journal Classification (ASJC) codes

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology


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