Clinical applications of susceptibility weighted MR imaging of the brain - A pictorial review

Bejoy Thomas, Sivaraman Somasundaram, Krishnamoorthy Thamburaj, Chandrasekharan Kesavadas, Arun Kumar Gupta, Narendra K. Bodhey, Tirur Raman Kapilamoorthy

Research output: Contribution to journalArticlepeer-review

166 Scopus citations


Introduction: Susceptibility-weighted imaging (SWI) is a novel magnetic resonance (MR) technique that exploits the magnetic susceptibility differences of various tissues, such as blood, iron and calcification. This pictorial review covers many clinical conditions illustrating its usefulness. Methods: SWI consists of using both magnitude and phase images from a high-resolution, three-dimensional fully velocity-compensated gradient echo sequence. Phase mask is created from the MR phase images, and multiplying these with the magnitude images increase the conspicuity of the smaller veins and other sources of susceptibility effects, which is depicted using minimal intensity projection (minIP). Results: The phase images are useful in differentiating between diamagnetic and paramagnetic susceptibility effects of calcium and blood, respectively. This unique MR sequence will help in detecting occult low flow vascular lesions, calcification and cerebral microbleed in various pathologic conditions and aids in characterizing tumors and degenerative diseases of the brain. This sequence also can be used to visualize normal brain structures with conspicuity. Conclusion: Susceptibility-weighted imaging is useful in differentiating and characterizing diverse brain pathologies.

Original languageEnglish (US)
Pages (from-to)105-116
Number of pages12
Issue number2
StatePublished - Feb 2008

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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