Clinical findings in primary orbital lymphoma

N. A. Stathopoulos, S. H. Goldberg, H. A. Al Mondhiry

Research output: Contribution to journalArticlepeer-review


Purpose: To examine the presenting signs and symptoms, clinical features, and response to therapy of primary orbital lymphoma. Methods: A retrospective study of eighteen patients diagnosed with biopsy proven orbital lymphoma between 1982 and 1995 was undertaken. Patients included had primary orbital disease with a negative work-up for systemic lymphoma, which included CT scanning and bone marrow biopsy. Five of the group were male and thirteen female. Mean age at presentation was 65 years of age (range 34-85). Four patients had bilateral disease noted after evaluation. The mean follow-up time was 40.2 months (range 9-124) Results: Analysis of location revealed 13/18 primarily in the orbit, 3/18 in the conjunctiva, and 2/18 in the eyelid. Three of the orbital lesions involved the lacrimal gland as well. Clinical signs on presentation included proptosis (10/18), ptosis (5/18), visible mass (13/18), and diplopia (2/18). Fifteen patients (17 orbits) were treated with radiation, two received chemotherapy, and one expired of unrelated causes prior to therapy. The mean dose of radiation was 2887 cGy (range 2160-4140). All patients responded to therapy with one patient having a recurrence and two with positive lymph nodes after therapy. Complications after therapy included dry eye (6/18) and cataract (2/18). Conclusion: Orbital lymphoma may present with mass, proptosis, and/or ptosis. When isolated to the orbit, the lesions respond well to therapy though there may be long term complications.

Original languageEnglish (US)
Pages (from-to)S752
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - Feb 15 1996

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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