TY - JOUR
T1 - Clinical presentation and course of depression in youth
T2 - Does onset in childhood differ from onset in adolescence?
AU - Birmaher, Boris
AU - Williamson, Douglas E.
AU - Dahl, Ronald E.
AU - Axelson, David A.
AU - Kaufman, Joan
AU - Dorn, Lorah D.
AU - Ryan, Neal D.
N1 - Funding Information:
This work was supported by NIMH grant 5 PO1 MH41712 . The authors acknowledge the assistance of Carol Kostek in manuscript preparation.
PY - 2004/1
Y1 - 2004/1
N2 - Objective: To simultaneously and prospectively compare the clinical presentation, course, and parental psychiatric history between children and adolescents with major depressive disorder. Method: A group of prepubertal children (n = 46) and postpubertal adolescents (n = 22) were assessed with structured interviews for psychopathology and parental psychiatric history and followed once every 2 years for approximately 5 years. Results: With the exception of more depressive melancholic symptoms in the adolescents, both groups had similar depressive symptomatology, duration (average 17 months), severity of the index episode, rates of recovery (85%) and recurrence (40%), comorbid disorders, and parental psychiatric history. Female sex, increased guilt, prior episodes of depression, and parental psychopathology were associated with worse longitudinal course. Conclusions: In general, major depressive disorder is manifested similarly in children and adolescents, and both groups have a protracted clinical course and high family loading for psychiatric disorders.
AB - Objective: To simultaneously and prospectively compare the clinical presentation, course, and parental psychiatric history between children and adolescents with major depressive disorder. Method: A group of prepubertal children (n = 46) and postpubertal adolescents (n = 22) were assessed with structured interviews for psychopathology and parental psychiatric history and followed once every 2 years for approximately 5 years. Results: With the exception of more depressive melancholic symptoms in the adolescents, both groups had similar depressive symptomatology, duration (average 17 months), severity of the index episode, rates of recovery (85%) and recurrence (40%), comorbid disorders, and parental psychiatric history. Female sex, increased guilt, prior episodes of depression, and parental psychopathology were associated with worse longitudinal course. Conclusions: In general, major depressive disorder is manifested similarly in children and adolescents, and both groups have a protracted clinical course and high family loading for psychiatric disorders.
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U2 - 10.1097/00004583-200401000-00015
DO - 10.1097/00004583-200401000-00015
M3 - Article
C2 - 14691361
AN - SCOPUS:3042703054
SN - 0890-8567
VL - 43
SP - 63
EP - 70
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 1
ER -
