Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants

Carmen D. Zorrilla; Russell Van Dyke; Arlene Bardeguez; Edward P. Acosta; Betsy Smith; Michael D. Hughes; Sharon Huang; D. Heather Watts; Barbara Heckman; Eleanor Jiménez; George McSherry; Lynne Mofenson

doi:10.1128/AAC.00871-06

Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants

Carmen D. Zorrilla, Russell Van Dyke, Arlene Bardeguez, Edward P. Acosta, Betsy Smith, Michael D. Hughes, Sharon Huang, D. Heather Watts, Barbara Heckman, Eleanor Jiménez, George McSherry, Lynne Mofenson

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).

Original language	English (US)
Pages (from-to)	2208-2210
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	51
Issue number	6
DOIs	https://doi.org/10.1128/AAC.00871-06
State	Published - Jun 2007

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Zorrilla, C. D., Van Dyke, R., Bardeguez, A., Acosta, E. P., Smith, B., Hughes, M. D., Huang, S., Watts, D. H., Heckman, B., Jiménez, E., McSherry, G., & Mofenson, L. (2007). Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants. Antimicrobial agents and chemotherapy, 51(6), 2208-2210. https://doi.org/10.1128/AAC.00871-06

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title = "Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants",

abstract = "Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).",

author = "Zorrilla, {Carmen D.} and {Van Dyke}, Russell and Arlene Bardeguez and Acosta, {Edward P.} and Betsy Smith and Hughes, {Michael D.} and Sharon Huang and Watts, {D. Heather} and Barbara Heckman and Eleanor Jim{\'e}nez and George McSherry and Lynne Mofenson",

year = "2007",

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doi = "10.1128/AAC.00871-06",

language = "English (US)",

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journal = "Antimicrobial agents and chemotherapy",

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Zorrilla, CD, Van Dyke, R, Bardeguez, A, Acosta, EP, Smith, B, Hughes, MD, Huang, S, Watts, DH, Heckman, B, Jiménez, E, McSherry, G & Mofenson, L 2007, 'Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants', Antimicrobial agents and chemotherapy, vol. 51, no. 6, pp. 2208-2210. https://doi.org/10.1128/AAC.00871-06

Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants. / Zorrilla, Carmen D.; Van Dyke, Russell; Bardeguez, Arlene et al.
In: Antimicrobial agents and chemotherapy, Vol. 51, No. 6, 06.2007, p. 2208-2210.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants

AU - Zorrilla, Carmen D.

AU - Van Dyke, Russell

AU - Bardeguez, Arlene

AU - Acosta, Edward P.

AU - Smith, Betsy

AU - Hughes, Michael D.

AU - Huang, Sharon

AU - Watts, D. Heather

AU - Heckman, Barbara

AU - Jiménez, Eleanor

AU - McSherry, George

AU - Mofenson, Lynne

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AB - Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).

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JO - Antimicrobial agents and chemotherapy

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Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants

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