Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants

Carmen D. Zorrilla; Russell Van Dyke; Arlene Bardeguez; Edward P. Acosta; Betsy Smith; Michael D. Hughes; Sharon Huang; D. Heather Watts; Barbara Heckman; Eleanor Jiménez; George McSherry; Lynne Mofenson

doi:10.1128/AAC.00871-06

Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants

Carmen D. Zorrilla
, Russell Van Dyke
, Arlene Bardeguez
, Edward P. Acosta
, Betsy Smith
, Michael D. Hughes
, Sharon Huang
, D. Heather Watts
, Barbara Heckman
, Eleanor Jiménez
, George McSherry
, Lynne Mofenson

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).

Original language	English (US)
Pages (from-to)	2208-2210
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	51
Issue number	6
DOIs	https://doi.org/10.1128/AAC.00871-06
State	Published - Jun 2007

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/AAC.00871-06

Cite this

Zorrilla, C. D., Van Dyke, R., Bardeguez, A., Acosta, E. P., Smith, B., Hughes, M. D., Huang, S., Watts, D. H., Heckman, B., Jiménez, E., McSherry, G., & Mofenson, L. (2007). Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants. Antimicrobial agents and chemotherapy, 51(6), 2208-2210. https://doi.org/10.1128/AAC.00871-06

@article{43705fa76f824f9681a705921d2ff30f,

title = "Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants",

abstract = "Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).",

author = "Zorrilla, \{Carmen D.\} and \{Van Dyke\}, Russell and Arlene Bardeguez and Acosta, \{Edward P.\} and Betsy Smith and Hughes, \{Michael D.\} and Sharon Huang and Watts, \{D. Heather\} and Barbara Heckman and Eleanor Jim{\'e}nez and George McSherry and Lynne Mofenson",

year = "2007",

month = jun,

doi = "10.1128/AAC.00871-06",

language = "English (US)",

volume = "51",

pages = "2208--2210",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "6",

}

Zorrilla, CD, Van Dyke, R, Bardeguez, A, Acosta, EP, Smith, B, Hughes, MD, Huang, S, Watts, DH, Heckman, B, Jiménez, E, McSherry, G & Mofenson, L 2007, 'Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants', Antimicrobial agents and chemotherapy, vol. 51, no. 6, pp. 2208-2210. https://doi.org/10.1128/AAC.00871-06

Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants. / Zorrilla, Carmen D.; Van Dyke, Russell; Bardeguez, Arlene et al.
In: Antimicrobial agents and chemotherapy, Vol. 51, No. 6, 06.2007, p. 2208-2210.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants

AU - Zorrilla, Carmen D.

AU - Van Dyke, Russell

AU - Bardeguez, Arlene

AU - Acosta, Edward P.

AU - Smith, Betsy

AU - Hughes, Michael D.

AU - Huang, Sharon

AU - Watts, D. Heather

AU - Heckman, Barbara

AU - Jiménez, Eleanor

AU - McSherry, George

AU - Mofenson, Lynne

PY - 2007/6

Y1 - 2007/6

N2 - Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).

AB - Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).

UR - https://www.scopus.com/pages/publications/34250171196

UR - https://www.scopus.com/pages/publications/34250171196#tab=citedBy

U2 - 10.1128/AAC.00871-06

DO - 10.1128/AAC.00871-06

M3 - Article

C2 - 17420209

AN - SCOPUS:34250171196

SN - 0066-4804

VL - 51

SP - 2208

EP - 2210

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 6

ER -

Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this