Clinical significance of hyperkeratosis and parakeratosis in otherwise negative Papanicolaou smears

Joel I. Sorosky, Paul F. Kaminski, John B. Wheelock, Edward S. Podczaski

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

To ascertain the clinical significance of hyperkeratosis and parakeratosis in otherwise negative Papanicolaou smears, we retrospectively reviewed 96 patients with these findings seen during a 32-month period. Evaluation included repeating the smear and performing colposcopy in all patients. Colposcopically directed biopsy and endocervical curettage were performed when appropriate. Only one patient had human papillomavirus (HPV) infection. The isolated finding of hyperkeratosis or parakeratosis was not associated with an increased incidence of cervical intraepithelial neoplasia or HPV and, clinically, was not associated with uterine descensus or vaginal prolapse.

Original languageEnglish (US)
Pages (from-to)132-134
Number of pages3
JournalGynecologic Oncology
Volume39
Issue number2
DOIs
StatePublished - Nov 1990

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynecology

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