@inproceedings{d06be08a269b4750b3afc8cbf0ca9f5c,
title = "Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array",
abstract = "Circulating tumor cells (CTCs) in peripheral blood are implicated in the spread of cancer by metastasis. CTCs are associated with worse survival and have been demonstrated as a prognostic biomarker in various cancer types. We have developed a flexible micro spring array (FMSA) device for antigen-independent viable-enrichment of CTCs from whole blood based on cell size and deformability. CTCs were enriched from twenty blood samples obtained from advanced non-small cell lung cancer (NSCLC) patients and quantified through immunocytochemical detection. CTC detection was correlated to a significant decrease in patient survival demonstrating the clinical relevance of FMSA-enriched CTCs in NSCLC.",
author = "R. Harouaka and X. Liu and W. Khan and T. Khan and S. Rice and C. Belani and Zheng, {S. Y.}",
note = "Publisher Copyright: {\textcopyright} 14CBMS.; 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",
year = "2014",
language = "English (US)",
series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",
publisher = "Chemical and Biological Microsystems Society",
pages = "579--581",
booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",
}
